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- Title
Potassium channels in animal models of post-traumatic stress disorder: mechanistic and therapeutic implications.
- Authors
Rajkumar, Ravi Philip
- Abstract
This article explores the role of potassium channels in animal models of post-traumatic stress disorder (PTSD) and their potential therapeutic implications. Potassium channels are important in regulating brain function and have been associated with various neuropsychiatric disorders. Animal models have shown that different types of potassium channels play a role in fear-related behaviors and memory. Genome-wide association studies have identified genes involved in fear and stress responses that may contribute to vulnerability to PTSD. Specific potassium channel subtypes have been implicated in the development of certain PTSD symptoms and may be potential targets for treatment. Activation or inhibition of these channels can affect fear responses and consolidation of fear memories. The article acknowledges the need for further research in humans and the limitations of the available evidence. The document provides a list of references for library patrons conducting research on the neurobiology of fear and PTSD, covering topics such as ion channels, pharmacological interventions, and genetic factors associated with PTSD.
- Subjects
POTASSIUM channels; BRAIN-derived neurotrophic factor; PRENATAL alcohol exposure; FEAR in animals; TRANSMEMBRANE domains; NEURAL circuitry; AMYGDALOID body
- Publication
Frontiers in Cellular Neuroscience, 2024, p1
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2024.1441514