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- Title
Effects of Electro-Acupuncture on IGF-I Expression in Spared Dorsal Root Ganglia and Associated Spinal Dorsal Horn in Cats Subjected to Adjacent Dorsal Root Ganglionectomies.
- Authors
Ping Dai; Zhao-Jun Wang; Wei-wei Sun; Jiang-xia Pang; Chao You; Ting-Hua Wang
- Abstract
The effects of electro-acupuncture (EA) on insulin-like growth factor-I (IGF-I) expression in the spared dorsal root ganglia (DRG) and associated spinal dorsal horns were explored in cats subjected to unilateral removal of L1–L5 and L7–S2 DRG, sparing the L6 DRG. Immunohistochemistry revealed the presence of IGF-I immunoreactive products in the L6 DRG neurons and some neurons and glial cells in the spinal cord. Western blot demonstrated that the level of IGF-I was significantly up-regulated both in the spared DRG and the dorsal horns of L3 and L6 cord segments at both 7 and 14 days post operation following EA. The present findings demonstrated the association between neuroplasticity and IGF-I expression, suggesting the possible role of IGF-I in EA promoted spinal cord plasticity.
- Subjects
ELECTROACUPUNCTURE; INSULIN-like growth factor-binding proteins; SPINAL ganglia; NEURONS; NEUROGLIA; NEUROPLASTICITY; IMMUNOHISTOCHEMISTRY; CATS as laboratory animals
- Publication
Neurochemical Research, 2009, Vol 34, Issue 11, p1993
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-009-9970-3