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- Title
Therapeutic effect of β-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.
- Authors
Dong-Yun Zhan; Morimoto, Sachio; Cheng-Kun Du; Yuan-Yuan Wang; Qun-Wei Lu; Tanaka, Atsushi; Ide, Tomomi; Miwa, Yoshikazu; Takahashi-Yanaga, Fumi; Sasaguri, Toshiyuki
- Abstract
Aims: Extensive clinical studies have demonstrated that β-adrenoceptor blocking agents (β-blockers) are beneficial in the treatment of chronic heart failure, which is due to various aetiologies, including idiopathic dilated cardiomyopathy (DCM) and ischaemic heart disease. However, little is known about the therapeutic efficacy of β-blockers in the treatment of the inherited form of DCM, of which causative mutations have recently been identified in various genes, including those encoding cardiac sarcomeric proteins. Using a mouse model of inherited DCM with a troponin mutation, we aim to study the treatment benefits of β-blockers.
- Subjects
BETA adrenoceptors; CARDIOMYOPATHIES; VENTRICULAR fibrillation; SUDDEN death; HEART failure
- Publication
Cardiovascular Research, 2009, Vol 84, Issue 1, p64
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvp168