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- Title
Peginterferon alpha-2b plus ribavirin for chronic hepatitis C virus mixed genotype infection.
- Authors
Ching-Chung Lin; Chia-Hsien Wu; Huan-Lin Chen; I-Tsung Lin; Shen-Yung Wang; Tsang-En Wang; Horng-Yuan Wang; Shou-Chuan Shih; Ming-Jong Bair
- Abstract
Background and aim. The treatment efficacy of peginterferon plus ribavirin for patients with HCV genotype 1 is inferior to that in patients with HCV genotype 2, but the efficacy among patients with mixed HCV genotype 1 + 2 is less clear. We compared the treatment outcome of peginterferon alpha-2b plus ribavirin among naïve chronic hepatitis C patients in Taiwan with HCV genotype 1 and 2, and mixed genotype 1 + 2. Material and methods. In this retrospective cohort study, 150 patients were treated with peginterferon alpha-2b once weekly, plus ribavirin, for 24 weeks. The endpoint was sustained virological response after receiving at least one dose of the study medication. Results. There were no differences in clinical characteristics among the 3 groups. There were significant differences in rapid virological response rate between patients with genotype 1 and genotype 2 (64.7 vs. 85.5%, respectively; p < 0.05) and a sustained virological response rate (55.9 vs. 83.6%, respectively; p = 0.001). The rapid virological response rate differed between the genotype 1 and mixed genotype 1 + 2 groups (64.7 vs. 85.2%, respectively; p < 0.05), but the sustained virological response rate was similar (55.9 vs. 74.1%; p = 0.101). Conclusions. Using peginterferon alpha-2b plus ribavirin for 24 weeks to treat patients with HCV genotype 1 + 2 achieved a 74.1% sustained virological response rate; the treatment efficacy was not inferior to patients with HCV genotype 1, but the percentage of liver cirrhosis in mixed genotype 1 + 2 group was higher to 22%, it is worth to be appropriately valued and studied.
- Subjects
GENETIC polymorphisms; RIBAVIRIN; NUCLEOSIDES; HEPATITIS C virus; VIROLOGY
- Publication
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology, 2014, Vol 13, Issue 4, p350
- ISSN
1665-2681
- Publication type
Article
- DOI
10.1016/s1665-2681(19)30841-5