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- Title
Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement?
- Authors
Bos, E. M.; Leuvenink, H. G. D.; van Goor, H.; Ploeg, R. J.
- Abstract
Major improvements in immunosuppressive treatment, surgical techniques, and treatment of post-transplant complications have contributed considerably to improved outcome in renal transplantation over the past decades. Yet, these accomplishments have not led to similar improvements in transplant outcome when the results of living and deceased donors are compared. The enormous demand for donor kidneys has allowed for the increase in acceptance of suboptimal donors. The use of brain dead patients as organ donors has had a tremendous positive influence on the number of renal transplants. Unfortunately, the physiologically abnormal state of brain death has a negative effect on transplant outcome. The fact that transplanted kidneys derived from brain dead donors have a decreased viability indicates that potential grafts are already damaged before retrieval and preservation. In this review, we present an overview of the current knowledge of (patho)-physiological effects of brain death and its relevance for renal transplant outcome. In addition, several options for therapeutic intervention during brain death in the donor with the goal to improve organ viability and transplant outcome are discussed.Kidney International (2007) 72, 797–805; doi:10.1038/sj.ki.5002400; published online 25 July 2007
- Subjects
KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; NON-heart-beating organ donation; ORGAN donors; URINARY organs; OPERATIVE surgery; NEPHROLOGY
- Publication
Kidney International, 2007, Vol 72, Issue 7, p797
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002400