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- Title
Effects of vitamin C infusion and vitamin E-coated membrane on hemodialysis-induced oxidative stress.
- Authors
C.-C. Yang; S.-P. Hsu; M.-S. Wu; S.-M. Hsu; C.-T. Chien
- Abstract
Chronic hemodialysis (HD) patients manifest anemia and atherosclerosis with associated oxidative stress. We explored whether intravenous infusion of vitamin C (VC) and/or use of vitamin E (VE)-coated dialysis membrane could palliate HD-evoked oxidative stress. Eighty patients undergoing chronic HD were enrolled and randomly assigned into four groups: HD with intravenous VC (n=20), HD with VE-coated dialyzer (n=20), HD with both (n=20), and HD with neither (n=20). We evaluated oxidative stress in blood and plasma, erythrocyte methemoglobin/ferricyanide reductase (red blood cells (RBC)-MFR) activity, plasma methemoglobin, and pro-inflammatory cytokines in these patients. All patients showed marked increases (14-fold) in blood reactive oxygen species (ROS) after HD. The types of ROS were mostly hydrogen peroxide, and in lesser amounts, O2•− and HOCl. HD resulted in decreased plasma VC, total antioxidant status, and RBC-MFR activity and increased plasma and erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and methemoglobin. Intravenous VC significantly palliated HD-induced oxidative stress, plasma and RBC levels of PCOOH, and plasma methemoglobin levels and preserved RBC-MFR activity. The VE-coated dialyzer effectively prevented RBCs from oxidative stress, although it showed a partial effect on the reduction of total ROS activity in whole blood. In conclusion, intravenous VC plus a VE-coated dialyzer is effective in palliating HD-evoked oxidative stress, as indicated by hemolysis and lipid peroxidation, and by overexpression of proinflammation cytokines in HD patients. Using VE-coated dialyzer per se is, however, effective in reducing lipid peroxidation and oxidative damage to RBCs.Kidney International (2006) 69, 706–714. doi:10.1038/sj.ki.5000109; published online 4 January 2006
- Subjects
HEMODIALYSIS; VITAMIN C; VITAMIN E; BLOOD; MEMBRANE proteins; OXIDATIVE stress; BLOOD filtration
- Publication
Kidney International, 2006, Vol 69, Issue 4, p706
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5000109