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- Title
Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand <sup>11</sup>C-DASB in healthy humans.
- Authors
Talbot, Peter S.; Frankle, W. Gordon; Hwang, Dah-Ren; Huang, Yiyun; Suckow, Raymond F.; Slifstein, Mark; Abi-Dargham, Anissa; Laruelle, Marc
- Abstract
Although abnormal serotonin (5-HT) function is implicated in a range of mental disorders, there is currently no method to directly assess 5-HT synaptic levels in the living human brain. The in vivo binding of some dopamine (DA) radioligands such as 11C-raclopride is affected by fluctuations in endogenous DA, thus providing an indirect measure of DA presynaptic activity. Attempts to identify a serotonergic radiotracer with similar properties have proved unsuccessful. Here, we investigated in humans the effects of reduced synaptic 5-HT on the in vivo binding of the 5-HT transporter (SERT) radioligand 11C-DASB, using Positron Emission Tomography (PET) and the rapid tryptophan depletion (RTD) technique. Eight (8) subjects (5M, 3F) were scanned with 11C-DASB under control and reduced endogenous 5-HT conditions, in a within-subject, double-blind, counterbalanced, crossover design. Regional distribution volumes (VT) were calculated using kinetic modeling and metabolite-corrected arterial input function. 11C-DASB specific binding was estimated as binding potential (BP) and specific to nonspecific equilibrium partition coefficient (V
- Publication
Synapse, 2005, Vol 55, Issue 3, p164
- ISSN
0887-4476
- Publication type
Article
- DOI
10.1002/syn.20105