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- Title
Doxorubicin-Bioconjugated Cadmium Sulfide Dextrin Quantum Dots for Imaging Cells.
- Authors
DE LA CRUZ, G. GONZALEZ; RODRIGUEZ-FRAGOSO, P.; MASTACHE-JUAREZ, A.; REYES-ESPARZA, J.; LOURDES, L. RODRÍGUEZ-FRAGOSO
- Abstract
In this investigation, quantum dots of cadmium sulfide semiconductor crystals capped with dextrin and bioconjugated with doxorubicin were used to target and provide imaging of HeLa cells, which play a critical role in cervical cancer. These dextrin-capped cadmium sulfide nanoparticles/semiconductor quantum dots bioconjugated with doxorubicin are in the range of 5 nm in size and exhibit an intense fluorescence emission in the green and red spectrum, which benefited fluorescence imaging on HeLa cells. Results obtained showed that dextrin-capped cadmium sulfide nanoparticles/semiconductor quantum dots bioconjugated with doxorubicin have a large accumulation time in cells distributed in the cytoplasm and nucleus, where the pharmacological effects of drugs are enhanced. Cells treated with dextrin-capped cadmium sulfide nanoparticles/semiconductor quantum dots bioconjugated with doxorubicin also showed a major increase in size, including cytoplasm and nucleus, as compared to cells treated with doxorubicin alone. Additionally, binucleated cells and membrane blebbing was also found. Therefore, dextrin-capped cadmium sulfide nanoparticles/semiconductor quantum dots bioconjugated with doxorubicin could be used as probes for simultaneous cell cancer-targeted fluorescent imaging, tracking and monitoring cell viability with the advantage of improving the clinical effects of antineoplastic drugs with increasing apoptosis.
- Subjects
CADMIUM sulfide; SEMICONDUCTOR quantum dots; CELL imaging; QUANTUM dots; PHARMACOLOGY; ANTINEOPLASTIC agents; HUMAN papillomavirus vaccines
- Publication
Indian Journal of Pharmaceutical Sciences, 2020, Vol 82, Issue 2, p230
- ISSN
0250-474X
- Publication type
Article
- DOI
10.36468/pharmaceutical-sciences.643