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- Title
Novel Anthraquinone-based Derivatives as Potent Inhibitors for Receptor Tyrosine Kinases.
- Authors
STASEVYCH, M.; ZVARYCH, V.; LUNIN, V.; HALENOVA, T.; SAVCHUK, O.; DUDCHAK, O.; VOVK, M.; NOVIKOV, V.
- Abstract
The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied compounds, were discovered.
- Subjects
ANTHRAQUINONE derivatives; PROTEIN-tyrosine kinases; ENZYME inhibitors; ANTINEOPLASTIC agents; DRUG development; THIAZOLES; AMINO acids
- Publication
Indian Journal of Pharmaceutical Sciences, 2015, Vol 77, Issue 5, p634
- ISSN
0250-474X
- Publication type
Article
- DOI
10.4103/0250-474X.169062