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- Title
The genomic landscape of juvenile myelomonocytic leukemia.
- Authors
Toretsky, Jeffrey A; Olshen, Adam B; Getz, Gad; Gruber, Tanja A; Golub, Todd R; Stegmaier, Kimberly; Loh, Mignon L; Stieglitz, Elliot; Chang, Tiffany Y; Gelston, Laura C; Esquivel, Emilio; Yu, Ariel; Archambeault, Sophie L; Beckman, Kyle; Cooper, Todd; Dahl, Gary V; Emanuel, Peter D; Liu, Y Lucy; Fluchel, Mark N; Goyal, Rakesh K
- Abstract
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies. In addition, few molecular pathways aside from the RAS-MAPK pathway have been identified that could serve as the basis for such novel therapeutic strategies. We therefore sought to genomically characterize serial samples from patients at diagnosis through relapse and transformation to acute myeloid leukemia to expand knowledge of the mutational spectrum in JMML. We identified recurrent mutations in genes involved in signal transduction, splicing, Polycomb repressive complex 2 (PRC2) and transcription. Notably, the number of somatic alterations present at diagnosis appears to be the major determinant of outcome.
- Subjects
MONOCYTIC leukemia; CHILDHOOD cancer; STEM cell transplantation; GENETIC mutation; EPSTEIN-Barr virus; DIAGNOSIS
- Publication
Nature Genetics, 2015, Vol 47, Issue 11, p1326
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.3400