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- Title
An Update on Implant-Associated Malignancies and Their Biocompatibility.
- Authors
Keane Tahmaseb, Grace C.; Keane, Alexandra M.; Foppiani, Jose A.; Myckatyn, Terence M.
- Abstract
Implanted medical devices are widely used across various medical specialties for numerous applications, ranging from cardiovascular supports to orthopedic prostheses and cosmetic enhancements. However, recent observations have raised concerns about the potential of these implants to induce malignancies in the tissues surrounding them. There have been several case reports documenting the occurrence of cancers adjacent to these devices, prompting a closer examination of their safety. This review delves into the epidemiology, clinical presentations, pathological findings, and hypothesized mechanisms of carcinogenesis related to implanted devices. It also explores how the surgical domain and the intrinsic properties and biocompatibility of the implants might influence the development of these rare but serious malignancies. Understanding these associations is crucial for assessing the risks associated with the use of medical implants, and for developing strategies to mitigate potential adverse outcomes.
- Subjects
MEDICAL specialties &; specialists; BIOCOMPATIBILITY; ORTHOPEDIC implants; BREAST implants; PROSTHETICS; MEDICAL equipment; ARTIFICIAL implants
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 9, p4653
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25094653