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- Title
Glucose tolerance modifies the effects of high-viscosity hydroxypropylmethylcellulose on postprandial glucose and insulin excursions.
- Authors
Maki, Kevin C.; Carson, Michael L.; Miller, Marvin P.; Turowski, Maciej; Bell, Marjorie; Wilder, Donna M.; Reeves, Matthew S.
- Abstract
High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a dietary fiber that forms a viscous gel in the gastrointestinal tract after consumption. The aim of the present analysis was to evaluate the influence of glucose tolerance on postprandial responses to HV-HPMC. Subjects were classified into low (LPG) or high (HPG) subgroups based on the median peak glucose concentration (< or ≥147 mg/dL) after a control test meal containing 75 g of carbohydrate. Those with HPG (n=16) did not differ from the LPG subset (n=15) in demographic characteristics or fasting insulin, but had significantly higher fasting glucose (99 vs. 91 mg/dL, p=0.006). Postprandial glucose (7882 vs. 5122 minx mg/dL, p=0.023) and insulin (5184 vs. 2739 min x mU/L, p=0.019) incremental areas under the curves (IAUC, 0-120 min) were higher in the HPG subjects. Adding HV-HPMC (4 or 8 g) to the meal reduced glucose and insulin responses (p<0.001). The degree of blunting of the insulin IAUC did not differ between the HPG and LPG subsets (-47 vs. -43%, p=0.671), but the glucose IAUC was blunted to a larger degree in the HPG subjects (-41 vs. -26%, p=0.034). Thus, slowing the rate of glucose absorption with HV-HPMC had a larger impact on postprandial glycemia in subjects with HPG. These findings may have implications for understanding how slowing carbohydrate absorption may influence diabetes risk.
- Subjects
GLUCOSE; VISCOSITY; ETHYLCELLULOSE; DIETARY fiber; INSULIN
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA178
- ISSN
0892-6638
- Publication type
Article