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- Title
4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo.
- Authors
Shing-Yi Sean Wu; David Wang, Hui-Min; Yi-Shan Wen; Wangta Liu; Pin-Hui Li; Chien-Chih Chiu; Pei-Chin Chen; Chiung-Yao Huang; Jyh-Horng Sheu; Zhi-Hong Wen
- Abstract
In this study, we screened compounds with skin whitening properties and favorable safety profiles from a series of marine related natural products, which were isolated from Formosan soft coral Cladiella australis. Our results indicated that 4-(phenylsulfanyl)butan-2-one could successfully inhibit pigment generation processes in mushroom tyrosinase platform assay, probably through the suppression of tyrosinase activity to be a non-competitive inhibitor of tyrosinase. In cell-based viability examinations, it demonstrated low cytotoxicity on melanoma cells and other normal human cells. It exhibited stronger inhibitions of melanin production and tyrosinase activity than arbutin or 1-phenyl-2-thiourea (PTU). Also, we discovered that 4-(phenylsulfanyl)butan-2-one reduces the protein expressions of melanin synthesis-related proteins, including the microphthalmiaassociated transcription factor (MITF), tyrosinase-related protein-1 (Trp-1), dopachrome tautomerase (DCT, Trp-2), and glycoprotein 100 (GP100). In an in vivo zebrafish model, it presented a remarkable suppression in melanogenesis after 48 h. In summary, our in vitro and in vivo biological assays showed that 4-(phenylsulfanyl)butan-2-one possesses anti-melanogenic properties that are significant in medical cosmetology.
- Subjects
MELANOGENESIS; PHENOL oxidase; MICROPHTHALMIA; TRANSCRIPTION factors; DOPACHROME tautomerase
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 9, p20240
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms160920240