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- Title
The Cross-Bridge of Skeletal Muscle Is Not Synchronized Either by Length or Force Step.
- Authors
Grazi, Enrico
- Abstract
Force and length steps, applied to a muscle fiber in the isometric state, are believed to synchronize attached cross-bridges. This alleged synchronization facilitates the interpretation of the experiments. A rapid force step elicits an elastic response of the attached cross-bridges, followed by an isotonic phase. The decay of this second isotonic phase is of the first order. This excludes that the attached cross-bridges may decay all at the same time. The change of the X-ray interference distance during the second phase measures the stroke size only in the unrealistic case that the cross-bridges are and remain all attached. A rapid force step does not synchronize attached cross-bridges. The change of X-ray interference during the second phase does not measure the stroke size. These conclusions significantly change the picture of the mechanism of skeletal muscle contraction.
- Subjects
MUSCLE cells; X-ray interference; SKELETAL muscle; MUSCLE contraction; MUSCLE physiology
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 6, p12064
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms160612064