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- Title
Thyroid function in children with Prader-Willi syndrome in Southern China: a single-center retrospective case series.
- Authors
Huang, Xinjiang; Yin, Xi; Wu, Dongyan; Cai, Yanna; Li, Xiuzhen; Zhang, Wen; Zeng, Chunhua; Mao, Xiaojian; Liu, Li
- Abstract
<bold>Background: </bold>To investigate hypothalamic-pituitary-thyroid function in children of different ages, nutritional phases, and genotypes that were diagnosed with Prader-Willi syndrome (PWS), as well as the effects of recombinant human growth hormone (rhGH) treatment on thyroid hormones in PWS patients.<bold>Methods: </bold>One hundred and thirty PWS patients (87 boys and 43 girls) aged from newborn to 15 years (y) (median 1.25 y, mean, SD: 2.95 ± 3.45 y), were surveyed in this study. Serum thyroid hormone levels were examined at least once per3-6 months during the 2 years follow-up study. Central hypothyroidism (C-HT) was identified as low/normal thyroid-stimulating hormone (TSH) and low free thyroxine 4 (FT4).<bold>Results: </bold>All study participants had normal neonatal TSH screening test results. The prevalence of C-HT is 36.2% (47/130). No C-HT cases were diagnosed in PWS either below 1 month (m) or above 12 y. The prevalence of C-TH would be increased with age before 3 y until reaching the peak, followed by a gradual decline over the years. The prevalence of C-HT varies significantly at different ages (Pearson's χ2 = 19.915; p < 0.01). However, there is no correlation between the C-HT prevalence and nutritional phases (Pearson's χ2 = 4.992; p = 0.288), genotypes (Pearson's χ2 = 0.292; p = 0.864), or rhGH therapy (Pearson's χ2 = 1.799; p = 0.180).<bold>Conclusions: </bold>This study suggests the prevalence of C-TH was increased with the age before 3 y, and reached the peak in the 1 to 3 y group, then gradually declined over the years. There is no correlation between C-HT prevalence and nutritional phases, genotypes, or rhGH treatment.
- Subjects
CHINA; PRADER-Willi syndrome; HUMAN growth hormone; CONGENITAL hypothyroidism; THYROID diseases; THYROID gland; SYNDROMES in children; THYROID hormones; PRADER-Willi syndrome diagnosis; THYROTROPIN; RETROSPECTIVE studies; RESEARCH funding; LONGITUDINAL method
- Publication
BMC Pediatrics, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2431
- Publication type
journal article
- DOI
10.1186/s12887-022-03275-5