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- Title
Structure-based design of a new class of highly selective pyrazolo[3,4-d]pyrimidines based inhibitors of cyclin dependent kinases.
- Authors
Ibrahim, Diaa A.; El-Metwally, Amira M.; Al-Arab, Elham E.
- Abstract
Structure-based design approach was successfully used to guide the evolution of a pyrazolo[3,4-d]pyrimidine scaffold yielding a new structural class of highly selective inhibitors of cyclin dependent kinases capable to interact with an identified part of the protein. Several compounds from this series displayed potent and selective activity against CDK2.
- Subjects
PYRAZOLONES; PYRIMIDINES; CHEMICAL inhibitors; CYCLIN-dependent kinases; CHEMICAL modification of proteins; PROTEIN-protein interactions; CYTOSKELETAL proteins; BIOACTIVE compounds; SELECTIVE exposure
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2009, p12
- ISSN
1551-7004
- Publication type
Article