We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
When It Is Better to Regress: Dynamics of Vascular Pruning.
- Authors
Ricard, Nicolas; Simons, Michael
- Abstract
Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
- Subjects
NEOVASCULARIZATION; BLOOD-vessel development; CAPILLARIES; LYMPHATICS; BIOLOGY
- Publication
PLoS Biology, 2015, Vol 13, Issue 5, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1002148