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- Title
Oropharyngeal carcinoma in fanconi anemia patient - Radiation treatment, toxicity, and a year follow-up: Case report.
- Authors
Antony, Febin; Raphael, Jomon C.; Varghese, Mathew K.; Gopu, Paul
- Abstract
Fanconi anemia (FA) is an inherited bone marrow failure disorder. In patients with FA, there is a high incidence of head and neck squamous cell carcinoma (HNSCC). As there is a defective DNA repair mechanism, radiotherapy (RT) or chemotherapy has an increased risk of toxicity in FA patients with HNSCC. We report the radiation treatment for oropharyngeal carcinoma in a FA patient. Our patient was treated with RT to a total dose of 60 Gy in 30 fractions. She developed grade 3 oral mucositis, grade 3 neutropenia, and thrombocytopenia at 20 Gy which resulted in treatment break of 11 days. She again developed grade 3 mucositis, grade 2 dermatitis, grade 3 thrombocytopenia, worsening of odynophagia at 44 Gy which resulted in a treatment break of 19 days. She completed RT and is now disease-free for 1 year with a good quality of life.
- Subjects
FANCONI'S anemia; MUCOSITIS; DNA repair; SQUAMOUS cell carcinoma; QUALITY of life; CARCINOMA
- Publication
Indian Journal of Cancer, 2021, Vol 58, Issue 3, p434
- ISSN
0019-509X
- Publication type
case study
- DOI
10.4103/ijc.IJC_162_20