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- Title
Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study.
- Authors
Sivaradjy, Monika; Gunalan, Anitha; Priyadarshi, Ketan; Madigubba, Haritha; Rajshekar, Deepashree; Sastry, Apurba S.
- Abstract
Introduction: Vancomycin-resistant enterococci (VRE) are emerging as an important multidrug-resistant pathogen causing nosocomial infections, predominantly bacteremia and urinary tract infections. VRE bacteremia has caused a significant increase in the duration of the hospital stay and mortality and had caused high public health threat due to limited treatment options. Materials and methods: Between October 2017 and September 2020, all consecutive patients with culture-proven bloodstream infection with Enterococcus species, isolated for the first time, were included in the study. A total of 427 Enterococcus species were identified, and antimicrobial susceptibility tests were performed and interpreted using Clinical and Laboratory Standard Institute guidelines. Results: Of the total 427 Enterococcus species isolated, 63 (45.6%) were VRE. Among them, 51/63 (81%) were Enterococcus faecium (E. faecium) and 5/63 (8%) were Enterococcus faecalis. There was an increased trend of VRE rate in the bloodstream infections of 6.12% (2018), 13.2% (2019), and 19.2% (2020). The majority of the VRE patients [43/63 (68%)] were admitted to the intensive care units (ICUs). Vancomycin A (VanA) is the most common phenotype isolated from 51/63(81%) patients. Conclusion: This increasing trend of VRE bacteremia is a red alert to the clinicians and the infection control practitioners, so that strict antibiotic policies and proper adherence to the infection control practices can be initiated to reduce the VRE rate.
- Subjects
INDIA; ANTIBIOTICS; CROSS infection prevention; VANCOMYCIN resistance; ENTEROCOCCAL infections; BACTEREMIA; INTENSIVE care units; ENTEROCOCCUS faecium; SCIENTIFIC observation; CROSS infection; TERTIARY care; GENTAMICIN; INFECTION control; LINEZOLID; ENTEROCOCCUS; AMPICILLIN; PEPTIDE antibiotics; QUINOLONE antibacterial agents; LONGITUDINAL method; MICROBIAL sensitivity tests
- Publication
Indian Journal of Critical Care Medicine, 2021, Vol 25, Issue 8, p881
- ISSN
0972-5229
- Publication type
Article
- DOI
10.5005/jp-journals-10071-23916