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- Title
A new ratiometric fluorescence probe as strong sensor of surface charge of lipid vesicles and micelles
- Authors
Singh, Yashveer; Gulyani, Akash; Bhattacharya, Santanu
- Abstract
We report on the ability of a new fluorescent probe, 4-(2-pyren-1-yl-vinyl) pyridine, <B>1</B>, to respond to micelles and phospholipid vesicles of different surface charge. The probe gets incorporated into micellar and membranous assemblies and shows a large red-shift in the fluorescence emission maxima especially when the surface charge of the organized media is anionic. The effect on the photo-excitation of the probe is very clear and pronounced as it can be easily visualized. The sample color upon photo-excitation changes from blue to orange/red once the probe experiences negatively charged vesicular or micellar surfaces. These results make the probe molecule useful as a reporter for sensing electrostatic environment in biological membranes and related organized assemblies.
- Subjects
BIOLOGICAL membranes; COATED vesicles
- Publication
FEBS Letters, 2003, Vol 541, Issue 1-3, p132
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00314-4