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- Title
Chromatin insulators: lessons from the fly.
- Authors
Gurudatta, B. V.; Corces, Victor G.
- Abstract
Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Drosophila has at least five different types of insulators; recent results suggest that these different insulators share some components that may allow them to function through common mechanisms. Data from genome-wide localization studies of insulator proteins indicate a possible functional specialization, with different insulators playing distinct roles in nuclear biology. Cells have developed mechanisms to control insulator activity by recruiting specialized proteins or by covalent modification of core components. Current results suggest that insulators set up cell-specific blueprints of nuclear organization that may contribute to the establishment of different patterns of gene expression during cell differentiation and development.
- Subjects
CHROMATIN; DNA-protein interactions; DNA; PROTEINS; CHROMOSOMES
- Publication
Briefings in Functional Genomics & Proteomics, 2009, Vol 8, Issue 4, p276
- ISSN
1473-9550
- Publication type
Article
- DOI
10.1093/bfgp/elp032