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- Title
tert-Butoxide-Mediated Arylation of 2-Substituted Cyanoacetates with Diaryliodonium Salts.
- Authors
Qian, Xiaofei; Han, Jianwei; Wang, Limin
- Abstract
A transition metal-free direct arylation of 2-substituted cyanoacetates with diaryliodonium salts was developed. With this approach, a wide range of α-tolunitrile derivatives has been synthesized in good to excellent yields of 45-92%. Furthermore, the practicability of this approach is further manifested in the synthesis of a related bioactive agent of glutarimide.
- Subjects
ARYLATION; NITRILE synthesis; NITRILE derivatives; NUCLEOPHILES; TRANSITION metal compounds synthesis; NUCLEOPHILIC reactions
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 6, p940
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201501013