We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A systematic evaluation of the potential of PCTA-NCS ligand as a bifunctional chelating agent for design of Lu radiopharmaceuticals.
- Authors
Pandey, Usha; Gamre, Naresh; Kumar, Yogendra; Shetty, Priyalatha; Sarma, Haladhar; Dash, Ashutosh
- Abstract
This paper explores the utility of para isothiocyanato benzyl 3,6,9,15-tetraazabicyclo [9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA-NCS) as a bifunctional chelating agent for Lu in comparison to para isothiocyanato benzyl 1,4,7,10-tetra aza cyclododecane tetraacetic acid (DOTA-NCS). The Lu-PCTA-NCS complex could be obtained in high radiolabeling yields at ambient temperature and exhibited excellent stability in vitro. Influence of trace metal ions on the radiolabeling yields was also evaluated. Biodistribution studies revealed no significant retention of Lu-PCTA-NCS in any vital organ at 24 h p.i. It could be concluded from our study that PCTA-NCS could be a potential BFCA for design of Lu radiopharmaceuticals.
- Subjects
RADIOPHARMACEUTICALS; CHELATING agents; MEDICAL radiology; RADIOPHARMACOLOGY; NUCLEAR medicine; RADIOACTIVE substances; ANALYTICAL radiochemistry; NUCLEAR chemistry
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2016, Vol 307, Issue 1, p187
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-015-4281-4