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- Title
Dosimetric study of radium-223 chloride and Sm-EDTMP for treatment of bone metastases using MCNPX code and available experimental data.
- Authors
Bagheri, R.; Afarideh, H.; Ghannadi-Maragheh, M.; Bahrami-Samani, A.; Shirmardi, S.
- Abstract
Radium-223 chloride is an alpha emitter radiopharmaceutical which recently has been used for treatment of bone metastases. Absorbed and equivalent doses of RaCl were studied using MCNPX Monte Carlo code in a phantom consisted of bone marrow, bone and soft tissue. Sm-EDTMP as a beta emitter was also simulated for comparison with RaCl. Results show that by injection of 100 µCi RaCl against 70 mCi Sm-EDTMP to a 70 kg adult man, equivalent dose of metastatic bone can be increased about six times without significant increase in delivered dose to healthy tissues. These results demonstrated acceptable agreement with experimental data.
- Subjects
RADIATION dosimetry; CHLORIDES; RADIUMTHERAPY; ETHYLENEDIAMINE; BONE metastasis; THERAPEUTICS
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2015, Vol 303, Issue 3, p1991
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-014-3641-9