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- Title
Synthesis of Alternating Polyisocyanate Copolymers by Anionic Polymerization for Mimicking Amphiphilic Helical Peptides.
- Authors
Bak, In Gyu; Chae, Chang‐Guen; Choi, Jieun; Song, Woo‐Young; Seo, Jiwon; Lee, Eunji; Lee, Jae‐Suk
- Abstract
The amphiphilic conformation of α‐helical peptides has important biological functions, such as ion transport, antifreeze, and innate immunity, which can be mimicked by alternating polyisocyanate copolymers. We synthesized poly(allyl isocyanate‐alt‐(S)‐(−)‐α‐methylbenzyl isocyanate (P(AIC‐alt‐SMBIC)) and ammonium‐containing P(AIC‐alt‐SMBIC) (N‐P(AIC‐alt‐SMBIC)), ensuring the amphiphilic helical conformation. The benzyl group of SMBIC plays an important role in alternating copolymerization with its steric and electron‐withdrawing effects, while AIC provides an alkene group capable of introducing a customized functional group. The P(AIC‐alt‐SMBIC) with predominantly alternating sequence was acquired at fSMBIC/fAIC=8 with a controlled molecular weight and narrow dispersity. N‐P(AIC‐alt‐SMBIC)s were synthesized from thiol‐ene radical addition with P(AIC‐alt‐SMBIC).
- Subjects
ADDITION polymerization; PEPTIDES; BENZYL group; MOLECULAR weights; BLOCK copolymers
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 51, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202212398