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- Title
Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus.
- Authors
Li, Mu-Yang; Zhu, Xin-Ming; Niu, Xiao-Tian; Chen, Xiu-Mei; Tian, Jia-Xin; Kong, Yi-Di; Zhang, Dong-Ming; Zhao, Lei; Wang, Gui-Qin
- Abstract
The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. A basal diet was supplemented with AMRP at 0, 1, 1.5 or 2 g/kg feed for 56 days. After the 56 days feeding period, weight gain (WG), specific growth rate (SGR) and feed conversion ratio (FCR) were significantly increased or decreased (P < 0.05) by dietary AMRP, with the highest WG, SGR and the minimum FCR occurring in 1.5 g/kg AMRP group. Furthermore, AMRP supplementation conferred significant protective effects against LPS challenge by preventing alterations in the levels of complements 3 (C3) and complements 4 (C4), lysozyme, superoxide dismutase (SOD), glutathione-S-transferase (GST), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) while regulating the expression of immune-related genes including heat shock protein 70 (HSP70), heat shock protein 90 (HSP90), SOD, GST, IL-1 and TNF-α. Finally, AMRP supplementation significantly increased serum total protein, albumin and globulin concentrations and reduced mortality after LPS challenge. Taken together, our results suggest that the administration of AMRP could attenuate LPS-induced negative effects in C. argus, with 1.5 g/kg considered a suitable dose.
- Subjects
HEAT shock proteins; IMMUNE response; ALLIUM; BLOOD proteins; SUPEROXIDE dismutase; WEIGHT gain
- Publication
Molecular Biology Reports, 2019, Vol 46, Issue 2, p2221
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-019-04677-y