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- Title
Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2.
- Authors
Satoh, Shinji; Yada, Ryoko; Inoue, Hiroko; Omura, Soichiro; Ejima, Emiko; Mori, Takahiro; Takenaka, Katsuhiko; Kawamura, Natsumi; Numaguchi, Kotaro; Mori, Etsuo; Asoh, Akemi; Nakamura, Toshihiro; Hiyamuta, Koji
- Abstract
Atherosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as compared with TLR-2 and patients with stable angina. Fifty-eight consecutive patients who underwent primary percutaneous coronary intervention (PCI, n = 29) because of ACS and elective PCI ( n = 29) because of stable angina using a filter-device distal protection device system were prospectively analyzed. mRNA levels of TLR-2 and TLR-4 in debris containing various inflammatory tissues entrapped in the filter device were altogether analyzed using real-time PCR. There were no significant differences in age, sex distribution, between stable angina and ACS groups. TLR-4 expression levels were higher in patients with ACS than in patients with stable angina. TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS.
- Subjects
TOLL-like receptors; TREATMENT of acute coronary syndrome; ATHEROSCLEROSIS; NATURAL immunity; PROTEIN expression; PERCUTANEOUS coronary intervention; LONGITUDINAL method
- Publication
Heart & Vessels, 2016, Vol 31, Issue 1, p1
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-014-0565-9