We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Blip up‐down acquisition for spin‐ and gradient‐echo imaging (BUDA‐SAGE) with self‐supervised denoising enables efficient T<sub>2</sub>, T<sub>2</sub>*, para‐ and dia‐magnetic susceptibility mapping.
- Authors
Zhang, Zijing; Cho, Jaejin; Wang, Long; Liao, Congyu; Shin, Hyeong‐Geol; Cao, Xiaozhi; Lee, Jongho; Xu, Jinmin; Zhang, Tao; Ye, Huihui; Setsompop, Kawin; Liu, Huafeng; Bilgic, Berkin
- Abstract
Purpose: To rapidly obtain high resolution T2, T2*, and quantitative susceptibility mapping (QSM) source separation maps with whole‐brain coverage and high geometric fidelity. Methods: We propose Blip Up‐Down Acquisition for Spin And Gradient Echo imaging (BUDA‐SAGE), an efficient EPI sequence for quantitative mapping. The acquisition includes multiple T2*‐, T2′‐, and T2‐weighted contrasts. We alternate the phase‐encoding polarities across the interleaved shots in this multi‐shot navigator‐free acquisition. A field map estimated from interim reconstructions was incorporated into the joint multi‐shot EPI reconstruction with a structured low rank constraint to eliminate distortion. A self‐supervised neural network (NN), MR‐Self2Self (MR‐S2S), was used to perform denoising to boost SNR. Using Slider encoding allowed us to reach 1 mm isotropic resolution by performing super‐resolution reconstruction on volumes acquired with 2 mm slice thickness. Quantitative T2 (=1/R2) and T2* (=1/R2*) maps were obtained using Bloch dictionary matching on the reconstructed echoes. QSM was estimated using nonlinear dipole inversion on the gradient echoes. Starting from the estimated R2/R2* maps, R2′ information was derived and used in source separation QSM reconstruction, which provided additional para‐ and dia‐magnetic susceptibility maps. Results: In vivo results demonstrate the ability of BUDA‐SAGE to provide whole‐brain, distortion‐free, high‐resolution, multi‐contrast images and quantitative T2/T2* maps, as well as yielding para‐ and dia‐magnetic susceptibility maps. Estimated quantitative maps showed comparable values to conventional mapping methods in phantom and in vivo measurements. Conclusion: BUDA‐SAGE acquisition with self‐supervised denoising and Slider encoding enables rapid, distortion‐free, whole‐brain T2/T2* mapping at 1 mm isotropic resolution under 90 s.
- Subjects
MAGNETIC resonance imaging
- Publication
Magnetic Resonance in Medicine, 2022, Vol 88, Issue 2, p633
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.29219