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- Title
Topical ruxolitinib: A new treatment for vitiligo.
- Authors
Tavoletti, G.; Avallone, G.; Conforti, C.; Roccuzzo, G.; Maronese, C. A.; Mattioli, M. A.; Quaglino, P.; Zalaudek, I.; Marzano, A. V.; Ribero, S.; Alberti‐Violetti, S.
- Abstract
Vitiligo is a chronic autoimmune skin disorder whose diagnosis is often psychologically upsetting. The efficacy of the available therapies, including topical corticosteroids and topical calcineurin inhibitors, has historically been limited and the management of vitiligo is still challenging. As vitiligo is a chronic disease limited to the skin, topical rather than systemic therapies may be preferable (especially among patients with localised lesions) to avoid the long‐term side‐effects of the latter. A topical formulation of ruxolitinib, a selective JAK1/2 inhibitor, has recently been approved in the United States for the treatment of non‐segmental vitiligo in patients aged >12 years based on data from the phase III TRuE‐V1 and TRuE‐V2 clinical trials. The aim of this review is to describe the current evidence concerning the efficacy and safety of topical ruxolitinib in the treatment of vitiligo, and discuss issues regarding its use in younger children and pregnant or breastfeeding women, as well as the duration and durability of treatment. The promising results obtained so far suggest that 1.5% ruxolitinib cream is an effective means of treating vitiligo.
- Subjects
UNITED States; VITILIGO; RUXOLITINIB; AUTOIMMUNE diseases; CALCINEURIN; SKIN diseases
- Publication
Journal of the European Academy of Dermatology & Venereology, 2023, Vol 37, Issue 11, p2222
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.19162