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- Title
Multicenter phase II study of antimicrobial prophylaxis in low-risk patients undergoing distal gastrectomy for gastric cancer.
- Authors
Imamura, Hiroshi; Furukawa, Hiroshi; Iijima, Shohei; Sugihara, Seichi; Tsujinaka, Toshimasa; Tsukuma, Hideaki; Shimokawa, Toshio
- Abstract
Background. In Japan, antimicrobial prophylaxis (AMP) is typically administered for 3 to 4 days postoperatively for clean-contaminated operations such as distal gastrectomy. This far exceeds the recommended 24 h or less laid out by the Centers for Disease Control (CDC) guidelines for the prevention of surgical-site infections (SSIs), after a cleancontaminated operation. Methods. Patients with gastric cancer, which was curable by distal gastrectomy with D2 lymphandectomy, were assigned to a multicenter phase II study. One gram of cefazolin within 30 min of the first surgical incision and intraoperative supplements of 1g of cefazolin every 3h were administered. AMP was not administered after skin closure unless postoperative infection occurred. The occurrence of SSIs was monitored until postoperative day 30 as the primary endpoint of this study. Results. In 56 patients, three SSIs (5.4%) and one remote site infection (1.8%) developed. No other postoperative infections were observed. Conclusion. Our data indicate that the CDC guidelines regarding AMP may also be sufficient for patients undergoing clean-contaminated operations in Japan.
- Subjects
ANTI-infective agents; DENTAL prophylaxis; STOMACH surgery; CANCER patients; GASTRECTOMY; INFECTION
- Publication
Gastric Cancer, 2006, Vol 9, Issue 1, p32
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-005-0354-3