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- Title
The Combined Anti-Aging Effect of Hydrolyzed Collagen Oligopeptides and Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Human Skin Fibroblasts.
- Authors
Zhu, Huimin; Guo, Xin; Zhang, Yongqing; Khan, Ajab; Pang, Yinuo; Song, Huifang; Zhao, Hong; Liu, Zhizhen; Qiao, Hua; Xie, Jun
- Abstract
Stem cell-derived exosomes (SC-Exos) are used as a source of regenerative medicine, but certain limitations hinder their uses. The effect of hydrolyzed collagen oligopeptides (HCOPs), a functional ingredient of SC-Exos is not widely known to the general public. We herein evaluated the combined anti-aging effects of HCOPs and exosomes derived from human umbilical cord mesenchymal stem cells (HucMSC-Exos) using a senescence model established on human skin fibroblasts (HSFs). This study discovered that cells treated with HucMSC-Exos + HCOPs enhanced their proliferative and migratory capabilities; reduced both reactive oxygen species production and senescence-associated β-galactosidase activity; augmented type I and type III collagen expression; attenuated the expression of matrix-degrading metalloproteinases (MMP-1, MMP-3, and MMP-9), interleukin 1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α); and decreased the expression of p16, p21, and p53 as compared with the cells treated with HucMSC-Exos or HCOPs alone. These results suggest a possible strategy for enhancing the skin anti-aging ability of HucMSC-Exos with HCOPs.
- Subjects
MESENCHYMAL stem cells; HUMAN stem cells; UMBILICAL cord; OLIGOPEPTIDES; SKIN regeneration; AGING prevention
- Publication
Molecules, 2024, Vol 29, Issue 7, p1468
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29071468