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- Title
Gonadotropin Releasing Hormone Agonist Final Oocyte Maturation and Human Chorionic Gonadotropin as Exclusive Luteal Support in Normal Responders.
- Authors
Beck-Fruchter, Ronit; Baram, Shira; Geslevich, Yoel; Weiss, Amir
- Abstract
<bold>Background/aims: </bold>Gonadotropin releasing hormone (GnRH) agonist triggering results in an endogenous gonadotropin flare. Although it effectively stimulates ovulation, GnRH agonist triggers results in an early luteolysis and requires modification of the luteal support. The current study aims to evaluate GnRH agonist triggering with exclusive human chorionic gonadotropin (hCG) luteal support.<bold>Methods: </bold>In this prospective observational study, 56 normogonadotropic-assisted reproductive technology patients, stimulated using a GnRH-antagonist protocol, were studied. Final oocyte maturation was achieved with 0.2 mg triptorelin acetate followed by progesterone free luteal support with human choriogonadotropin (1,500 IU * 2). A control group was selected from a pool of 1,023 normogonadotropic patients who received Choriogonadotropin alfa for final oocyte maturation and progesterone suppositories for luteal support.<bold>Results: </bold>No significant difference was found for the number of oocytes, oocyte maturation rate, fertilization and implantation rate, clinical pregnancy rate (25 vs. 26.7%) and live birth rate (25 vs. 21.4%). Progesterone levels in conception cycles were significantly higher in the study group than corresponding levels in the control group.<bold>Conclusion: </bold>GnRH agonist triggering with exclusive hCG support may be a valid alternative to hCG triggering with progesterone support. This protocol combines the potential advantages of a physiological trigger with a simple, patient-friendly, luteal support.
- Subjects
GONADOTROPIN releasing hormone; FROZEN human embryos; GONADOTROPIN; CHORIONIC gonadotropins; OVUM; REPRODUCTIVE technology; CHILDBIRTH; LUTEINIZING hormone releasing hormone antagonists; OVUM physiology; PROGESTERONE; DRUG therapy; HORMONE antagonists; BIRTH rate; FERTILIZATION in vitro; HUMAN reproduction; LONGITUDINAL method; INDUCED ovulation; CYTOMETRY; FETAL development; THERAPEUTICS
- Publication
Gynecologic & Obstetric Investigation, 2019, Vol 84, Issue 1, p27
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000490946