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- Title
Regression and disappearance of clinical symptoms in some cases of genodermatoses.
- Authors
Salamon, T.
- Abstract
Genetic skin diseases are usually thought of as stable phenotypes caused by a mutant gene. However, a review of the literature on genodermatoses and my personal experience with a number of these disorders show that the concept of a stable phenotype is not always true. A number of genodermatoses actually show a regression of symptoms. Among these are monilethrix, several types of erythrokeratoderma, several forms of palmoplantar keratoderma such as the varians Wachters type and the Richner-Hanhart syndrome, and some forms of epidermolysis bullosa, for example the Dowling-Meara type. Three different reasons possibly underlying the regression of symptoms in genetic diseases are briefly discussed: (1) environmental factors, (2) hormonal influences and (3) movable, transposable elements causing instability of the genome.
- Subjects
SKIN disease diagnosis; SKIN diseases; PHENOTYPES; DISEASE remission; PALMOPLANTAR keratoderma; EXFOLIATIVE dermatitis; CONGENITAL ichthyosiform erythroderma; DIAGNOSIS
- Publication
Dermatology (10188665), 1993, Vol 186, Issue 4, p245
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000247362