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- Title
Macropinocytosis: mechanisms and regulation .
- Authors
Salloum, Gilbert; Bresnick, Anne R.; Backer, Jonathan M.
- Abstract
Macropinocytosis is defined as an actin-dependent but coat- and dynamin-independent endocytic uptake process, which generates large intracellular vesicles (macropinosomes) containing a non-selective sampling of extracellular fluid. Macropinocytosis provides an important mechanism of immune surveillance by dendritic cells and macrophages, but also serves as an essential nutrient uptake pathway for unicellular organisms and tumor cells. This review examines the cell biological mechanisms that drive macropinocytosis, as well as the complex signaling pathways — GTPases, lipid and protein kinases and phosphatases, and actin regulatory proteins — that regulate macropinosome formation, internalization, and disposition.
- Subjects
PINOCYTOSIS; PHOSPHOPROTEIN phosphatases; PROTEIN kinases; EXTRACELLULAR fluid; NUTRIENT uptake; MEMBRANE lipids; COATED vesicles
- Publication
Biochemical Journal, 2023, Vol 480, Issue 5, p335
- ISSN
0264-6021
- Publication type
Article
- DOI
10.1042/BCJ20210584