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- Title
Synthesis of 10-alkylsulfanyl-substituted pyrido-[4',3':4,5]thieno[3,2- d]pyrimidines annulated with pyran, cyclohexane, and cyclopentane rings.
- Authors
Paronikyan, Ervand; Dashyan, Shushanik; Minasyan, Nune; Stepanyan, Grachya; Babaev, Evgene
- Abstract
[Figure not available: see fulltext.] We propose a single-step procedure for the synthesis of 8-oxo-10-sulfanylpyrido[4',3':4,5]thieno[3,2- d]pyrimidines, annulated with pyran, cyclohexane, or cyclopentane rings. The alkylation of these compounds in aqueous DMF solution of KOH at room temperature was shown to proceed regioselectively and led to the formation of S-substituted products. Amino- and alkoxy-substituted derivatives of tetracyclic thieno[3,2- d]pyrimidines were synthesized. The antimicrobial activity of the obtained compounds was studied on Grampositive staphylococci and Gram-negative rods.
- Subjects
PYRIDONE synthesis; PYRIDONE derivatives; PYRAN synthesis; CYCLOPENTANE synthesis; ANTI-infective agents
- Publication
Chemistry of Heterocyclic Compounds, 2016, Vol 52, Issue 5, p337
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-016-1887-6