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- Title
The Frequency of Tumor Necrosis Factor Alpha Gene Polymorphism in Patients with Chronic Immune Thrombocytopenia.
- Authors
Elsafy, Osama Roshdy; Mohamed, Marwa Zakaria; El Fattah, Nermin Raafat Abd; Elgohary, Nehal Tarek Anwer
- Abstract
Background: The aim of this study was to reveal the frequency of Necrosis Factor _Alpha Gene Polymorphism in evaluation of severity and outcome of chronic immune thrombocytopenia in pediatric department of Zagazig University hospitals. Methods: We conduct a retrospective case control on 40 children diagnosed with chronic ITP and 40 age and sex healthy matched subjects as a control recruited from outpatient hematology clinic Faculty of Medicine, Zagazig University. Results: We found a highly significant difference between ITP group and control group as regarding TNF-a alleles where A allele was expressed in 43.7% of cases versus 17.5% 0f control, P value<0.001.Our results showed that, the frequency of TNF-a gene polymorphism genotypes 308G<A (rs1800629) were more expressed in chronic ITP cases versus control group and there was a highly significant difference, P<0.001. We did not find statistically significant differences between patients out come and each of different geno-types of TNF-a, P value =0.128. Conclusion: The present study, suggests that possible significant association of TNF-a (rs1800629) A allele and 308G<A gene polymorphism in chronic ITP patients might play a role in disease susptability, genetic risk factor, pathogenesis, and development of chronicity.
- Subjects
TUMOR necrosis factor genetics; THROMBOCYTOPENIA; GENETIC polymorphisms; HEMATOLOGY; ALLELES
- Publication
Zagazig University Medical Journal, 2023, Vol 29, Issue 1, p155
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/zumj.2021.16776.1504