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- Title
Chemical Carcinogen (Dimethyl-benzanthracene) Induced Transplantable Cancer in Fanconi Anemia (Fanca--/--) Mice.
- Authors
EPPERLY, MICHAEL W.; MUKHERJEE, AMITAVA; FISHER, RENEE; SHIELDS, DONNA; HOU, WEN; HONG WANG; RIGATTI, LORA H.; GREEN, ANTHONY; HUQ, M. SAIFUL; GREENBERGER, JOEL S.
- Abstract
Background/Aim: Patients with radiation sensitive Fanconi anemia (FA) are presenting with cancers of the oral cavity, oropharynx, and other anatomic locations. Materials and Methods: Animal models for cancer in FA mice used orthotopic tumors from wild type mice. We derived a cancer cell line from Fanca--/-- mice by topical application of the chemical carcinogen dimethyl benzanthracene (DMBA). Results: A Fanca--/-- mouse rhabdomyosarcoma was derived from a Fanca--/-- (129/Sv) mouse. The in vitro clonogenic survival of the Fanca--/-- clone 6 cancer cell line was consistent with the FA genotype. Transplanted tumors demonstrated hypoxic centers surrounded by senescent cells. Conclusion: This Fanca--/-- mouse syngeneic cancer should provide a valuable resource for discovery and development of new normal tissue radioprotectors for patients with FA and cancer.
- Subjects
FANCONI'S anemia; OROPHARYNX; CANCER cells; BENZANTHRACENES; GENOTYPES
- Publication
In Vivo, 2023, Vol 37, Issue 6, p2421
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13347