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- Title
microRNA-260 在秀丽隐杆线虫衰老进程中的作用研究.
- Authors
张照康; BILLY, Kirpnda John; 努尔古丽.苏里坦; 杨利建
- Abstract
By using Caenorhahditis elegans (C. elegans) as a model animal - the effect of deletion of miR-260 coding gene in C. elegans was studied on lifespan-fertility-ability to eat and the ability to survive under the heat stress. In order to have better understanding on the mechanisms of how miR-260 regulate lifespan - the expression level of key genes in main aging pathways were investigated. The results showed that: miR-260 deletion strains have a shortened lifespan -reduced brood size- increased time attaining the low feed rate and decreased ability to survive under the heat stress* which speeding up the aging process. Its possible molecular mechanism is that deletion of miR-260 influenced the expression of eat-2 andjw£-l5 and regulated the aging process through dietary restriction pathway-TOR signaling pathway and JXK signaling pathway.
- Publication
Journal of Central China Normal University, 2016, Vol 50, Issue 6, p897
- ISSN
1000-1190
- Publication type
Article