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- Title
Molecular Layer Interneurons of the Cerebellum: Developmental and Morphological Aspects.
- Authors
Sotelo, Constantino
- Abstract
During the past 25 years, our knowledge on the development of basket and stellate cells (molecular layer interneurons [MLIs]) has completely changed, not only regarding their origin from the ventricular zone, corresponding to the primitive cerebellar neuroepithelium, instead of the external granular layer, but above all by providing an almost complete account of the genetic regulations (transcription factors and other genes) involved in their differentiation and synaptogenesis. Moreover, it has been shown that MLIs' precursors (dividing neuroblasts) and not young postmitotic neurons, as in other germinal neuroepithelia, leave the germinative zone and migrate all along a complex and lengthy path throughout the presumptive cerebellar white matter, which provides suitable niches exerting epigenetic influences on their ultimate neuronal identities. Recent studies carried out on the anatomical-functional properties of adult MLIs emphasize the importance of these interneurons in regulating PC inhibition, and point out the crucial role played by electrical synaptic transmission between MLIs as well as ephaptic interactions between them and Purkinje cells at the pinceaux level, in the regulation of this inhibition.
- Subjects
INTERNEURONS; CEREBELLUM development; TRANSCRIPTION factors; EPIGENETICS; PURKINJE cells; GENETIC regulation
- Publication
Cerebellum, 2015, Vol 14, Issue 5, p534
- ISSN
1473-4222
- Publication type
Article
- DOI
10.1007/s12311-015-0648-x