We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Complete improvement in a patient with multiple irreversible defects of the left ventricle on 99m technetium-sestamibi SPECT after percutaneous coronary intervention.
- Authors
Javadi, H.; Porpiranfar, M. A.; Semnani, S.; Jallalat, S.; Yavari, P.; Mogharrabi, M.; Hooman, A.; Amini, A.; Barekat, M.; Iranpour, D.; Assadi, M.; Asli, I. N.
- Abstract
99mTc-sestamibi has been investigated as a potential viability marker; initial studies have shown good concordance between 201TI and 99mTc-sestamibi activities in both viable and nonviable myocardium. However, assessment of myocardial viability by 99mTc-sestamibi remains controversial for tissue recovery after revascularization. Here, we present a patient with several regions of severely diminished and irreversible (defect persisting in both early and delay images of each set scanning) defects on initial scan which were dissolved completely on the follow up scan after an intervention. In a 75 year-old Asian woman with acute myocardial infarction who received thrombolytic therapy and subjected to percutaneous coronary angiography (PCI) on day 28 after acute myocardial infarction(MI), resting 99mTcsestamibi SPECT was applied on day 4 (initial scan) and 138 (follow up scan) after acute MI at 30 and 180 min after injection of tracer (740 MBq); Two-dimentional echocardiography was carried out at the same time. On the initial image set, there was irreversible defects in the apex, anteroapical, inferoapical, anteroseptal, septal and also anterior walls, while the follow up image was normal in all regions.The angiography intervention showed just significant stenosis on left anterior descending (LAD) vessel (95%). This may highlight the failure of 99mTc-sestamibi as a marker of myocardial viability and also mandate further validating of the procedure with follow up scan or other modalities for myocardial viability investigation.
- Subjects
TECHNETIUM isotopes; BIOMARKERS; MYOCARDIAL infarction; THROMBOLYTIC therapy; CORONARY angiography; ECHOCARDIOGRAPHY; CASE studies
- Publication
European Review for Medical & Pharmacological Sciences, 2012, Vol 16, p113
- ISSN
1128-3602
- Publication type
Article