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- Title
NMR structure and bactericidal activity of KR-12 analog derived from human LL-37 as a potential cosmetic preservative.
- Authors
Yun, Hyosuk; Min, Hye Jung; Lee, Chul Won
- Abstract
KR-12 was derived from the human antimicrobial peptide, LL-37. KR-12 maintains the antimicrobial activity of LL-37 and has low toxicity against human cells, thereby showing a high potential for various applications. In this study, the three-dimensional structure of KR-12 analog (KR-12-pa) was determined by solution NMR spectroscopy. The NMR structure of KR-12-pa revealed a nearly perfect amphipathic α-helical structure composed of multiple hydrophobic and positively charged residues. The minimal inhibitory concentration of KR-12-pa for various bacterial and yeast cells suggested that KR-12-pa has a much stronger antimicrobial activity than commercial cosmetic preservatives. In addition, KR-12-pa in cosmetic formulations showed much stronger bactericidal effects than conventional cosmetic preservatives and very low cytotoxicity to mammalian cells. These results suggest that KR-12-pa is applicable as a cosmetic preservative.
- Subjects
NUCLEAR magnetic resonance spectroscopy; BACTERIAL cells
- Publication
Journal of Analytical Science & Technology, 2020, Vol 11, Issue 1, p1
- ISSN
2093-3134
- Publication type
Article
- DOI
10.1186/s40543-020-00213-x