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- Title
Effect of Cholera Toxin Administered Supraspinally or Spinally on the Blood Glucose Level in Pain and D-Glucose Fed Animal Models.
- Authors
Yun-Beom Sim; Soo-Hyun Park; Yu-Jung Kim; Sung-Su Kim; Chea-Ha Kim; Su-Jin Kim; Jun-Sub Jung; Ohk-Hyun Ryu; Moon-Gi Choi; Seong-Soo Choi; Hong-Won Suh
- Abstract
In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment with CTX alone for 24 h dose-dependently increased the blood glucose level. However, i.c.v. treatment with CTX for 24 h did not affect the blood glucose level. When mice were orally fed with D-glucose (2 g/kg), the blood glucose level reached to a maximum level at 30 min and almost returned to the control level at 120 min after D-glucose feeding. I.c.v. pretreatment with CTX increased the blood glucose level in a potentiative manner, whereas i.t. pretreatment with CTX increased the blood glucose level in an additive manner in a D-glucose fed group. In addition, the blood glucose level was increased in formalin-induced pain animal model. I.c.v. pretreatment with CTX enhanced the blood glucose level in a potentiative manner in formalin-induced pain animal model. On the other hand, i.t. pretreatment with CTX increased the blood glucose level in an additive manner in formalin-induced pain animal model. Our results suggest that CTX administered supraspinally or spinally differentially modulates the regulation of the blood glucose level in D-glucose fed model as well as in formalin-induced pain model.
- Subjects
CHOLERA toxin; BLOOD sugar measurement; PHYSIOLOGICAL effects of formaldehyde; ANIMAL models in research; PAIN; COMPOSITION of feeds
- Publication
Korean Journal of Physiology & Pharmacology, 2013, Vol 17, Issue 2, p163
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2013.17.2.163