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- Title
Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences.
- Authors
Lippert, Jörg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michaël; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato
- Abstract
B Systems pharmacology integrates structural biological and pharmacological knowledge and experimental data, enabling dissection of organism and drug properties and providing excellent predictivity. OSP already hosts several general systems pharmacology activities (for an example, see the OSP Links Supplement: Glucose-Insulin Model[8]) addressing the broader scope of mechanistic disease and drug-response modeling. The current model library includes PBPK models of individual drugs in particular drug-drug interaction victims and perpetrators and sophisticated systems pharmacology models. The OSP management team is responsible for the development and maintenance of the OSP roadmap and the formal release of certified OSP suite versions, best practices, and the coordination of all community activities.
- Subjects
OPEN source software; PHARMACOLOGY; SCIENTIFIC models; SCIENCE education; SIMULATION methods &; models; COMMUNITIES
- Publication
CPT: Pharmacometrics & Systems Pharmacology, 2019, Vol 8, Issue 12, p878
- ISSN
2163-8306
- Publication type
Article
- DOI
10.1002/psp4.12473