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- Title
Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles.
- Authors
Chigbu, DeGaulle I.; Karbach, Nicholas J.; Abu, Sampson L.; Hehar, Navpreet K.
- Abstract
Allergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic predisposition. While our comprehension of the pathophysiological engagement of immune and nonimmune cells in the conjunctiva has progressed, the same cannot be asserted for the cytokines mediating this inflammatory cascade. In this review, we proffer a comprehensive description of interleukins 4 (IL-4), IL-5, IL-6, IL-9, IL-13, IL-25, IL-31, and IL-33, as well as thymic stromal lymphopoietin (TSLP), elucidating their pathophysiological roles in mediating the allergic immune responses on the ocular surface. Delving into the nuanced functions of these cytokines holds promise for the exploration of innovative therapeutic modalities aimed at managing allergic conjunctivitis.
- Subjects
ALLERGIC conjunctivitis; THYMIC stromal lymphopoietin; CYTOKINES; TH2 cells; IMMUNE response; INTERLEUKIN receptors
- Publication
Life (2075-1729), 2024, Vol 14, Issue 3, p350
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life14030350