We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease.
- Authors
Roumeliotis, Stefanos; Neofytou, Ioannis E.; Maassen, Cecile; Lux, Petra; Kantartzi, Konstantia; Papachristou, Evangelos; Schurgers, Leon J.; Liakopoulos, Vassilios
- Abstract
We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics' parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman's rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0.29, p < 0.001), dp-ucMGP (r = 0.43, p = < 0.0001), central diastolic blood pressure (DBP) (r = −0.19, p = 0.02), and albuminuria (r = −0.17, p = 0.03). NLR correlated with the duration of CVD (r = 0.32, p < 0.001), CRP (r = 0.27, p = 0.01), dp-ucMGP (r = 0.43, p < 0.0001), central DBP (r = −0.32, p < 0.0001) and eGFR (r = −0.25, p = 0.04). In multiple regression models, circulating dp-ucMGP was an independent predictor of RDW (β = 0.001, p = 0.001) and NLR (β = 0.002, p = 0.002). In CKD patients, RDW and NLR are associated with traditional and novel markers of VC and CVD.
- Subjects
ERYTHROCYTES; CHRONIC kidney failure; NEUTROPHIL lymphocyte ratio; DIASTOLIC blood pressure; ARTERIAL calcification; BLOOD cell count
- Publication
Metabolites (2218-1989), 2023, Vol 13, Issue 2, p303
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo13020303