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- Title
Editorial: Trauma-Induced, DAMP-Mediated Remote Organ Injury, and Immunosuppression in the Acutely Ill Patient.
- Authors
Pottecher, Julien; Meyer, Alain; Wenceslau, Camilla Ferreira; Timmermans, Kim; Hauser, Carl Jeffrey; Land, Walter Gottlieb
- Abstract
Highlights from the article: Indeed, according to the danger/injury model in immunology ([6], [7]), damage-associated molecular patterns (DAMPs) are massively released following severe musculoskeletal injury, which then bind to various receptors on the surface of and within neutrophils and elicit widespread systemic inflammation ([8]). For instance, membranes immobilized with nucleic acid-binding polymers, like hexadimethrine bromide, represent promising breakthroughs to dampen trauma-induced inflammation and remote organ injury, as exemplified by Aswani et al. In their clinical cohort of severe trauma patients, the authors show that patients who went on to develop secondary organ failures (acute lung injury in 93% of cases) had higher blood concentrations of mtDNA at only 2 h after injury.
- Subjects
IMMUNOSUPPRESSION; CENTRAL nervous system injuries; WOUNDS &; injuries; MESENCHYMAL stem cells
- Publication
Frontiers in Immunology, 2019, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2019.01971