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- Title
Cholinesterase Activity In Normal Healthy Adult Population Of Agrarian Kashmir Valley.
- Authors
Jan, Nasreen; Z. A., Wafai; Rather, Mohd Younis
- Abstract
Background: Cholinesterase is a family of enzymes that catalyze the hydrolysis of the neuro-transmitter Acetylcholine (ACh) into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Patients & Methods: Cholinesterase activity of small cohort of normal healthy population of Kashmir Valley was assessed in this study to evaluate the effect of chronic exposure of cholinesterase inhibitors on cholinesterase enzyme activity itself and hence establish our own (Kashmir Specific) baseline cholinesterase activity standards for diagnostic and prognostic interpretation, relevant to this population at present. Here we have assessed the cholinesterase enzyme activity in a cohort of normal healthy adult population possibly exposed to pesticides only through food chain without known exposure. Results: Interestingly our study has shown enhanced activity as hypothesized based on physiological compensatory regulations. Increased enzyme activity in Kashmiri population can be explained on the basis of rebound phenomenon in cholinesterase activity due to chronic subtle pesticide exposure. This may be advantageously exploited in terms of protection from chronic pesticide exposure. However extensive, large, horizontal study is warranted for conclusive evidence. Conclusion: Organophosphorus compounds are very rampantly used in Kashmir as insecticides and fungicides. Moreover, the geopolitical scenario is reportedly causing stress related high incidence of organophosphorus incidental poisoning. The results of this study besides having tremendous application in health sector may prove beneficial for Toxicological, Environmental, and Pollution control Agencies.
- Subjects
POLLUTION; ORGANOPHOSPHORUS compounds; CHOLINESTERASE inhibitors; ENZYME inhibitors; POPULATION
- Publication
JK Practitioner, 2019, Vol 24, Issue 1/2, p20
- ISSN
0971-8834
- Publication type
Article