We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies.
- Authors
Niktabar, Seyed Mohammadreza; Latifi, Seyed Mojtaba; Moghimi, Mansour; Jafari-Nedooshan, Jamal; Aghili, Kazem; Miresmaeili, Seyed Mohsen; Zare-Shehneh, Masoud; Neamatzadeh, Hossein
- Abstract
Introduction. Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results. Objective. To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies. Material and methods. We searched for eligible studies in the PubMed, Embase, and CNKI databases. A total of 40 case-control studies with 1,144 cases and 2,925 controls were included. Results. The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma. However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk. Conclusions. The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk.
- Subjects
RISK factors of skin cancer; VITAMIN D receptors; GENETIC polymorphisms
- Publication
Dermatology Review / Przeglad Dermatologiczny, 2019, Vol 106, Issue 3, p268
- ISSN
0033-2526
- Publication type
Article
- DOI
10.5114/dr.2019.86909