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- Title
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation.
- Authors
Groc, Laurent; Choquet, Daniel; Chaouloff, Francis
- Abstract
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.
- Subjects
CORTICOSTERONE; NEURAL transmission; NEUROTRANSMITTER receptors; NEURAL physiology; ADRENOCORTICAL hormones; SYNAPSES; THERAPEUTICS
- Publication
Nature Neuroscience, 2008, Vol 11, Issue 8, p868
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2150