We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Management of Post-transplant Hyperparathyroidism and Bone Disease.
- Authors
Delos Santos, Rowena; Coyne, Daniel; Rossi, Ana; Maw, Thin Thin
- Abstract
Significant advances in immunosuppressive therapies have been made in renal transplantation, leading to increased allograft and patient survival. Despite improvement in overall patient survival, patients continue to require management of persistent post-transplant hyperparathyroidism. Medications that treat persistent hyperparathyroidism include vitamin D, vitamin D analogues, and calcimimetics. Medication side effects such as hypocalcemia or hypercalcemia, and adynamic bone disease, may lead to a decrease in the drugs. When medical management fails to control persistent post-transplant hyperparathyroidism, treatment is a parathyroidectomy. Surgical techniques are not uniform between centers and surgeons. Undergoing the surgery may include a subtotal technique or a technique including total parathyroid gland resection with partial heterotopic gland reimplantation. In addition, there are possible post-surgical complications. The ideal treatment for persistent post-transplant hyperparathyroidism is the treatment and prevention of the condition while patients are being managed for their late-stage chronic kidney disease and end-stage renal disease.
- Subjects
TREATMENT of bone diseases; TREATMENT of chronic kidney failure; HYPERPARATHYROIDISM treatment; PARATHYROID gland surgery; THERAPEUTIC use of vitamin D; TREATMENT of surgical complications; HORMONE antagonists; ADRENALECTOMY; BONE diseases; HOMOGRAFTS; HYPERCALCEMIA; HYPOCALCEMIA; IMMUNOSUPPRESSION; KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; VITAMIN D; THERAPEUTICS
- Publication
Drugs, 2019, Vol 79, Issue 5, p501
- ISSN
0012-6667
- Publication type
Article
- DOI
10.1007/s40265-019-01074-4